Advances in Viral Genomes Research by John A. Borrelli, Ylenia D. Giannini

By John A. Borrelli, Ylenia D. Giannini

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1187-99. , Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo. Mol Ther, 2005. 12(5): p. 803-12. , HSV-1 amplicon-mediated post-transcriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation. Gene Ther, 2007. 14(15): p. 1143-51. M. Y. Lam, Targeting proliferating tumor cells via the transcriptional control of therapeutic genes. Cancer Gene Ther, 2006. 13(1): p. 44-52. M. Y. Lam, Glioma-specific and cell cycleregulated herpes simplex virus type 1 amplicon viral vector.

It should be taken into account that the decrease in GluN1, which is essential for assembly and for the membrane allocation of the receptor, would lead to a decrease of all the NMDAR subunits at the synaptic surface [112]. The genes for microtubule-associated protein tau (MAPT) and α-synuclein (SNCA) play central roles in neurodegenerative disorders. Peruzzi and colleagues have recently generated amplicon-based iBAC-vectors carrying either the 143-kb MAPT or the 135-kb SNCA loci [113]. They have used these vectors to study regulation of gene expression of both MAPT and SNCA, showing functional complementation between them in cultured neurons and in organotypic brain slices.

Amplicon Vectors for Gene Transfer 37 References [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] Fatahzadeh, M. A. Schwartz, Human herpes simplex labialis. Clin Exp Dermatol, 2007. 32(6): p. 625-30. , Functional roles of the tegument proteins of herpes simplex virus type 1. Virus Res, 2009. 145(2): p. 173-86. Grunewald, K. and M. Cyrklaff, Structure of complex viruses and virusinfected cells by electron cryo tomography. Curr Opin Microbiol, 2006. 9(4): p. 437-42. , Visualization of tegument-capsid interactions and DNA in intact herpes simplex virus type 1 virions.

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