African Horse Sickness by Philip S. Mellor, Matthew Baylis, Christopher Hamblin,

By Philip S. Mellor, Matthew Baylis, Christopher Hamblin, Charles H. Calisher, Peter P.C. Mertens

African horse illness virus is a double-stranded RNA virus which factors a non-contagious, infectious arthropod-borne sickness of equines and sometimes canine. 9 detailed, across the world recognized serotypes of the virus have to date been pointed out. This booklet relies upon the findings of 2 programmes funded by means of the ecu fee. it will likely be of worth not just to the professional examine staff but in addition to veterinary staff facing regulate and to legislators looking to advertise secure overseas move of equines. the themes lined comprise cutting-edge discussions on diagnostics, vaccines, molecular biology, vector stories, and epidemiology.

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It has also been shown here, that the AHSV 4 recovered from an infected, but apparently healthy donkey was lethal for a pony. Hence, infected donkeys could act as 'silent reservoirs' of AHSV, helping to maintain and spread the virus, even after vaccination. Although a viraemia was detected in all 6 donkeys following inoculation with AHSV 4, no secondary viraemia could be detected when 2 of these animals were challenged with a second AHSV serotype, AHSV 5. The VN data confirm that AHSV 5 did replicate sufficiently to elicit a primary, AHSV 5 type-specific response at 12 to 14 dpi.

The epidemiology of African horse sickness (AHS) in mules and donkeys is poorly documented as are their responses to vaccination. Furthermore, the effectiveness of vaccination in these species is difficult to assess since they do not usually exhibit significant clinical signs after infection. These studies were designed to assess viraemia and the development of antibodies in mules and donkeys following inoculation with AHSV 4 vaccine or wild-type AHSV 4, and subsequent to challenge with homologous wild-type virus.

Virus titres were calculated using the method of Spearmann and Karber [5] and were expressed as MLDso/g of tissue. Suspensions of homogenised tissue were assayed for viral antigen by indirect sandwich ELISA [8]. 15 for at least two consecutive dilutions were recorded as positive. Antigen titres were calculated using the method of Spearmann and Karber [5] and were expressed as loglO/g of tissue. Serogroup specific antibodies against AHSV were detected by titration in competitive ELISAs [7]. End-point titres were expressed as reciprocallogJO of the last dilution of serum 40 C.

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