AIDS-Associated Viral Carcinogenesis by C. Meyers

By C. Meyers

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54 AIDS-related NHLs are grouped into three distinct histologic categories, including small non-cleaved cell lymphoma, diffuse large-cell lymphoma, and anaplastic large-cell lymphoma. 55,56 BL and DLBCL will be discussed separately in the following sections. 57,58 AIDS-related BL are further discussed in this chapter. Table 2. AIDS-related lymphomas (WHO classification)54 Lymphomas also occurring in immunocompetent patients Burkitt’s lymphoma DLBCL: centroblastic, immunoblastic, and anaplastic variants Lymphomas occurring more specifically in HIV-infected patients Primary effusion lymphoma Plasmablastic lymphoma Lymphomas also occurring in other immunodeficiency states Polymorphic or post-transplant lymphoproliferative disorder-like B-cell lymphoma 2.

49 Lim and colleagues65 reviewed 363 individuals with ARL (including DLBCL and BL) from 1982 to 2003, including 262 in the pre-HAART era, and 101 in the HAART era. 2 months in DLBCL). 65 Cortes and colleagues used HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with high-dose methotrexate and cytarabine) regimen in 13 patients with HIV-related BL, nine of whom also received HAART. 66 While Wang and colleagues, in a retrospective study, compared 14 HIV-infected individuals with BL with 24 non-HIV-infected individuals with BL who received CODOX-M/IVAC (cyclophosphamide, doxorubicin, high-dose methotrexate/ifosfamide, etoposide, and high-dose cytarabine) or less intensive regimens.

2 months. Mortality from MCD and its resulting complications was 45% in this series. Steroids are generally used along with chemotherapy, thus results are limited in treatment for MCD. 226 42 AIDS-Associated Viral Oncogenesis Antiviral Therapy Inconsistent results have been reported in various studies from the use of antiviral therapy targeting HHV-8. For instance, remission of HIV-associated MCD, along with a decline in plasma HHV-8 DNA levels, was attained in three patients treated with intravenous ganciclovir therapy.

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