Alkaptonuria and Ochronosis by Jozef Rovenský, Tibor Urbánek, Boldišová Oľga, James A.

By Jozef Rovenský, Tibor Urbánek, Boldišová Oľga, James A. Gallagher

This booklet comprehensively describes alkaptonuria and ochronosis. starting with the heritage, genetics, pathophysiology and diagnostics of the ailment, the authors therefore current a close characterization of its medical manifestation within the backbone, peripheral joints, eyes, ears, visceral organs and respiration tract, its pathological anatomy and histology, in addition to differential analysis. this is often complemented by way of the most recent facts on treatment and experimental types of alkaptonuria, and supported by way of a number of case experiences. a number of photos and radiological pictures rfile the medical signs, giving the reader a superb knowing of the ailment. at the foundation of the editor’s and authors’ personal vast observations, the ebook deals an research of protein metabolism and fragrant amino acids within the context of alkaptonuria. Written by means of foreign specialists within the box, the ebook deals a worthwhile reference consultant for healthcare pros operating in rheumatology, dermatology, pulmonology, otolaryngology and histopathology.

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Extra resources for Alkaptonuria and Ochronosis

Sample text

It can be assumed that there are certain differences in the mechanism of development of regressive changes in both pathological conditions. Some differences in spine shape also confirm it. While we observe tendency to kyphotic curves in arthrotic spine, we can see apparent flattening (dos plat) in ochronosis. There is a more pronounced irregularity of contours of spinous processes in ochronotic spine. The most marked difference between these two diseases consists in overall dynamics of the development of symptoms.

The distance between both lines should not be smaller than 20 in 170 cm high individual. We designated this sign in abbreviated form as ‘lateroflexion × cm’. (d) Occiput-wall distance (fleche of J. Forestier). A patient stands towards the wall in such a way so that heels, dorsal part of knees, calves, back and, if possible, the occiput touching it. The patient has to hold their head in such a position so that lateral angle of the eye and upper insertion of the helix would be on the same horizontal straight line.

Engl. J. Med. 26, 2111–2121 (2002) Clinical Manifestation of Ochronotic Arthropathy in Spine 11 Jozef Rovenský and Tibor Urbánek Content References 52 The predominant clinical presentation of ochronotic arthropathy in the skeletal system is the spine, which was affected by the disease in all our patients. While observing the patients in initial stages of the disease as well as during more detailed analysis of medical history, we found out that except for a few cases, the first subjective and objective signs were localised in spine area.

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