Alzheimer's Disease: Methods and Protocols (Methods in by N. M. Hooper

By N. M. Hooper

A panel of hugely expert investigators describe intimately their cutting-edge biochemical, telephone organic, and molecular organic recommendations for learning the molecular foundation of Alzheimer's illness. those effectively reproducible, step by step equipment concentrate on paintings with the amyloid precursor protein and the amyloidogenic peptide A?, but in addition include-with the new id of presenilin proteins-techniques for choosing the constitution and organic functionality of those proteins. furthermore, there are chapters overlaying the tau protein and its position in Alzheimer's affliction, in addition to an introductory dialogue of the historical past of the disorder, its genetic foundation, and the at present to be had and attainable destiny healing brokers. state-of-the-art and large ranging, Alzheimer's ailment: tools and Protocols presents prepared entry to confirmed, reproducible tools for elucidating the molecular foundation of this most typical senile dementia.

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Extra resources for Alzheimer's Disease: Methods and Protocols (Methods in Molecular Medicine)

Sample text

Although AD is currently considered to be a heterogeneous disease, the most consistent risk fac to be implicated other than advancing age is the presence of a positive family history. This potential genetic vulnerabilityADtohas been recognized for some time. Some of the earliest evidence suggestive of a genetic contribution to AD came from Kallmann’s 1956 study ( I ) demonstrating a higher concordance rate in monozygotic twins for “parenchymatous senile dementia” compared with dizygotic twins and siblings.

80. Breen, K. , andAnderton, B. H. (1991) Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion. J. Neurosci. Res. 28,90-100. 81. , Roch, J. , Sundsmo, M. , Otero, D. , and Saitoh, T,(1993) Amino acid sequence R E M S represents the active domain of amyloid PIA4 protein J. 121,879-886. precursor that promotes fibroblast growth. D. , and 82. , Roch, J. , Otero, Saitoh, T. J. Neurosci. 14,5461-5470. 83. , Roch, J. , Jin, L. W. and Saitoh, T. (1994) Secreted form of amyloid P/A4 protein precursor (APP) binds to two distinct APP binding sites on rat B103 neuron-like cells through two different domains, but only one site is involved in neuritotropic activity.

Hendrie, H. , Hall,K. , Unverzagt, F. ,Yu, C. , et al. ( 1995)Apolipoprotein E genotypes and Alzheimer’s disease in a community stu of elderly African Americans. Ann. 37,118-120. 28. Tang, M. , et al. (1998) The ApoE-&4allele and the risk of Alzheimer’s disease among African-Americans, whites and Hispanics. JAMA 279,751-755. 29. Farrer, L. , Cupples, L. , Myers, R. , van Duijn, C. , et al. (1998)Effects of age and ethnicity on the 1inkbetweenApolipopt E genotype and Alzheimer disease: a meta-analysis.

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